Hello,

As the title suggests, I am working with the “symmetric space” template and attempting to convert ROI centerpoints from the “asymmetric” (FSL) space into symmetric space. However, the sym/asym atlases use substantially different coordinate systems. So far, I have tried several approaches including the one mentioned below, but I am not sure if they are correct. I suspect the “MNI coordinates” entered for the symmetric seeds from the following method may be incorrect, as they likely correspond to FSL’s default “asymmetric atlas” space.

What would be the ideal way to to get the actual MNI coordinates of our ROIs to sym space in FSL?

```
%%1. Create xform matrix
flirt -in MNI152_T1_1mm_asym -ref MNI152_T1_1mm_sym -omat asym_to_sym.mat
%% 2. transform a map (e.g. Julich) into sym space
flirt -in your_map -ref $FSLDIR/data/standard/MNI152_T1_2mm_sym_brain -applyxfm -init $FSLDIR/data/standard/asym_to_sym.mat -out your_map_in_sym_space
%% 3) warp our ROI in the same way
flirt -in your_ROI -ref $FSLDIR/data/standard/MNI152_T1_2mm_sym_brain -applyxfm -init $FSLDIR/data/standard/asym_to_sym.mat -out ROI_in_sym_space.nii.gz
%%4) Find the value of that max coordinate
fslstats /Users/.../lhem_ROI_sym.nii.gz -R
%% 5) Threshold the transformedPoint to get only the top voxel & binarize
fslmaths /Users/..../lhem_ROI_sym.nii.gz -thr x -bin /Users/.../sym_point.nii.gz
```