NiMARE ALE are results two-tailed?

Correct, and some day, with user contribution, Neurosynth Compose will have that level of detail. At the moment, however, it’s just not available.

It’s a separate Estimator, so you use it instead of the ALE and FWECorrector tools. It’s not compatible with any of the multiple comparisons correction methods in NiMARE, unfortunately, but it uses random group reassignments to build a null distribution. Here’s an example in our documentation that covers using it: NiMARE: Neuroimaging Meta-Analysis Research Environment — NiMARE 0.10.0 documentation