[ANN] Elderly Brain Template (1 mm, CC BY 4.0) — open dataset for aging neuroimaging

We publicly release an age-specific 1-mm T1 template for older adults (65+), together with
binary masks (GM/WM/CSF; brainstem, amygdala, caudate, hippocampus, pallidum, putamen, thalamus).
License: CC BY 4.0. No scientific content change across releases (voxel values / shape / affine identical).

What’s included

  • T1w template (176×208×176; L–R, P–A, I–S; qform/sform = Scanner Anat)
  • Binary masks for tissue classes and 7 subcortical nuclei
  • CSVs for Dice and whole-brain metrics (3D-SSIM, CC, MSE)
  • Brief convergence logs of the construction procedure

Quick start (registration with ANTs)

antsRegistrationSyN.sh -d 3 \
  -f tpl-Elderly/tpl-Elderly_res-01_T1w.nii.gz \
  -m subject_T1.nii.gz -o sub2ET_ -t s -n 8

Links
• OSF (public): https://osf.io/eavrj/ (DataLad: osf://eavrj)
• Dataset (version v1.1): https://doi.org/10.5281/zenodo.16827113
• GitHub (tree): https://github.com/KazumichiOta/elderly-brain-template/tree/main/tpl-Elderly
• Article (NeuroImage, 2025): https://doi.org/10.1016/j.neuroimage.2025.121473

Note: A submission to TemplateFlow is pending (PR #183). We will update this thread when it is accepted.

1 Like

Thank you for sharing this resource. I work with neuroimaging data from older populations from time to time, and finding age-appropriate templates has always been a challenge. Most pipelines still default to younger adult references, so it’s great to see a carefully constructed template specifically for the 65+ group being made openly available.

I also appreciate that you’ve included the masks, evaluation metrics, and convergence logs instead of only the final template. That level of transparency makes it much easier for others to understand and trust the construction process.

Looking forward to seeing it integrated into TemplateFlow. Thanks again for making the dataset and code openly accessible to the community.

1 Like

Thank you very much for your kind words. I am glad to hear that the motivation for this resource resonates with researchers working with older neuroimaging cohorts.
We also felt that age-appropriate templates are important for aging and clinical populations, particularly when ventricular enlargement and global atrophy are prominent. We therefore tried to make the template, masks, evaluation metrics, and construction logs openly available to support transparency and reuse.
At this stage, TemplateFlow integration is not feasible because of license-related compatibility issues, but the resource will remain publicly available through the current repositories. Thank you again for your encouraging feedback.