I want to run a binary SVM (or other classifier) discriminating patients versus controls based on their first-level con images, with unequal sample size (n=96 versus 65).
Is this scenario implemented in TDT and if yes, could you please help me setting up this analysis?
Yes, TDT supports this! Check out the templates folder and look at the between group template. Then mix that together with the unbalanced data template. I think unless you want to do subsampling, I would simply use AUC_minus_chance as a metric instead of accuracy_minus_chance and use the between group decoding. If you run into any errors, I hope that TDT will guide you but it should work out of the box mostly!