Difference between spike and HFOs in epilepsy

Hi, all. Does anyone know what’s the difference between spike and HFO in epilepsy, or a precise definition of this?

Thank you

Hi Barry,

From Frauscher et al., 2017. This article and those cited within will be helpful.

HFOs are defined as spontaneous EEG events in the frequency range between 80 and 500 Hz, consisting of at least four oscillations that clearly stand out from the background activity.1 HFOs are subdivided into ripples ranging from 80 to 250 Hz and fast ripples > 250 Hz.


Thanks a lot! I’ll dig into the article.