Diffuison tensor imaging - mean diffusion analysis - how to?

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Dear All,

I’m currently working on a DTI tractography group comparison and aiming to compare the mean diffusion values of specific seeds or ROIs.

My plan is to follow the standard FSL DTI analysis steps up to the final probabilistic estimation or probabilistic tracking (probtrackx - which I have already done). From there, I intend to back-transform the results into individual DTI space. So I could obtain mean diffusion values for comparison.

However, it is quite unclear for me, how to “back-transform” these output to individual spaces, and get results.

Could anyone provide guidance or assistance on how to proceed with this part of the analysis?

Thank you in advance!

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Hi @didatto,

I am not sure there is a “standard FSL DTI analysis” per se, but with the exception of whole-brain approaches (such as TBSS and fixel based analyses), DWI analyses and tractography are typically already in subject space. At what point are you leaving that space?

Best,
Steven