Does Voxel-based morphometry (VBM) refer to the preprocessing steps that involves segmentation?

Voxel-based morphometry (VBM) typically involves preprocessing steps that include segmentation of the brain into different tissue types, such as grey matter, white matter, and cerebrospinal fluid (CSF).
Can a preprocessing pipeline that does not involve tissue segmentation (but does involve registration and calculating Jacobian determinants to measure voxel changes) be considered also voxel-based morphometry?

Hi @Yasmine,

Voxel based morphometry typically refers to a statistical test in which some morphometric value of a voxel (e.g., volume) is a value of interest. Tissue segmentation is usually required as you typically do not care about cerebrospinal fluid, and may want to know if differences are in white vs gray matter.


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Could you please provide some good reference for this?

Exactly what I needed. Thank you so much!