Does Voxel-based morphometry (VBM) refer to the preprocessing steps that involves segmentation?

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Voxel-based morphometry (VBM) typically involves preprocessing steps that include segmentation of the brain into different tissue types, such as grey matter, white matter, and cerebrospinal fluid (CSF).
Can a preprocessing pipeline that does not involve tissue segmentation (but does involve registration and calculating Jacobian determinants to measure voxel changes) be considered also voxel-based morphometry?

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Hi @Yasmine,

Voxel based morphometry typically refers to a statistical test in which some morphometric value of a voxel (e.g., volume) is a value of interest. Tissue segmentation is usually required as you typically do not care about cerebrospinal fluid, and may want to know if differences are in white vs gray matter.

Best,
Steven

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Could you please provide some good reference for this?

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Exactly what I needed. Thank you so much!