Macro-scale Systemic Bioelectrical Synchronization (MSBS): A Possible Form of Large-scale Volume Transmission

Hello colleagues,

I’d like to share an extension of my previous open-science case study on Spontaneous Neuroelectrical Cascade (SNC) — a reproducible, non-pathological neurophysiological event characterized by whole-body tremor and autonomic activation.

In recent observations, a new pattern has emerged that differs from sequential SNC events. Instead of wave-like propagation, the electrical and muscular responses appear to occur simultaneously across the entire body, forming what I describe as a Macro-scale Systemic Bioelectrical Synchronization (MSBS).

This synchronized activation might represent a macro-scale manifestation of volume transmission, where bioelectrical fields or ionic flows could transiently couple multiple body systems beyond synaptic boundaries. The event is reproducible, short in duration (1–3 s), and associated with controlled intracranial pressure (ICP) modulation and measurable autonomic responses such as sweating and brief tremor coherence.

If verified, MSBS could bridge the gap between micro-level neuronal communication and large-scale systemic coordination, contributing to discussions on spontaneous brain activity and global brain-body coupling.

I’m sharing this description openly for feedback or theoretical insight from electrophysiology, bioelectricity, or systems neuroscience perspectives.

Thank you.
Triệu Vỹ Nguyễn