Permutation ROI-based decoding

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Hi all,

I am conducting actually a multi-voxel pattern analysis on several ROIs (x6), and several conditions (2 groups, 2 classes). I obtained accuracies (following a cross-validation scheme) and I need to know which ones are above chance level.

I would like to use permutations at the group level instead of binomial tests or t-tests. Then I conducted 1000 permutations for each condition and subjects.

My questions are:

  • What is the best way to compute my null distribution (e.g., randomly pick permutation values within each of my subjects)?
  • Do I have to compare the mean accuracy or the distribution of accuracy against the null distribution?
  • Do I have to adjust then each p-value for multiple comparisons (e.g., FDR)?

I hope my questions are clear…

Thanks,

Mathieu

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Have a look into the MVPA course by @Martin found here: https://fmrif.nimh.nih.gov/public/other-courses/mvpa
Lecture number 7 covers group statistics in MVPA analyses.

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