Quantified methods to evaluate the CT - MRI alignment?

1

Hi, all
I’m doing brain T1-MRI and CT registration. Are there any Quantified Methods could help evaluate the quality of the registration, besides the visual judgement?

Thanks!
Barry

2

One that jumps to the top of my head is the Dice Score, which is a measure of volume alignment. It would not be able to judge surface alignment, if that is important to you.

3

As I know, If I want to use Dice, it means I already have a ground-truth-aligned CT.
While in my case, I used dipy to register CT and MRI, and I want to calculate some indexes like R2, or mutual information to show the difference between the original CT and aligned CT, to tell us the quality of the registeration.