Is it possible to identify a stable self-referential neural pattern and transfer its dynamics to a neural organoid?

:brain: Question: Identifying and Potentially Transferring a Neural Pattern of “Self”

Hello,

I would like to ask the community a conceptual question that lies at the intersection of neuroscience, cognitive science, and neural engineering.

I am trying to understand — purely at a theoretical level — whether the following sequence is neurobiologically coherent, partially plausible, or fundamentally contradictory:

  1. identifying a neural pattern involved in self-referential processing (“I”, or the self ↔ world relation),

  2. attempting to synchronize this pattern with a neural organoid,

  3. and testing whether the organoid can partially reproduce or maintain that dynamic configuration.

This is not a claim that such a transfer is currently achievable.

My goal is to understand which parts contradict established neuroscience, and which are simply beyond current technology but do not violate first principles.

:small_blue_diamond: 1. Identifying a neural pattern of self-referential processing

By “pattern” I do not mean a fixed set of neurons, but a dynamic configuration — a distributed, stable profile of rhythms, phases, synchronies, and functional clusters that emerges during acts of self-awareness.

Question:

Are there studies indicating that a stable, individual-specific pattern of self-referential processing can be isolated using current methods (fMRI/MEG, dynamic connectivity analysis, optical recordings, etc.)?

:small_blue_diamond: 2. Synchronizing such a pattern with a neural organoid

If such a pattern can be at least partially characterized, the next conceptual step is to ask whether it could be used to drive or entrain an organoid.

Hypothetical framework:

• the organoid is derived from iPSCs,

• interfaced via MEA, optogenetics, or magnetic systems,

• and receives correlated oscillatory rhythms or activity from the host brain.

Questions:

• How realistic is deep phase or rhythm synchronization between a living brain and an organoid?

• Are there documented cases where an organoid reproduces the dynamics of an external neural network?

:small_blue_diamond: 3. Attempting a (speculative) dynamic “transfer”

If synchronization is achievable, a further speculative idea arises:

Could temporary suppression of the original brain activity lead the brain to “restore” the missing pattern through the interface — allowing part of the dynamic configuration to emerge inside the organoid as a compensatory process?

This leads to a broader conceptual question:

Can aspects of self-awareness be treated as transferable dynamic processes rather than strictly tissue-bound properties?

:small_blue_diamond: 4. Could an organoid maintain the pattern autonomously?

If the organoid continues to exhibit a similar dynamic configuration after the original brain cluster is inhibited:

• would this be merely an imitation?

• or could it be viewed as a partial functional transfer?

• where exactly is the boundary between those two interpretations?

:small_blue_diamond: 5. Linking the organoid to another brain

Finally — the most speculative step, yet important for understanding the conceptual limits.

If the organoid stores or maintains a fragment of the pattern, could it be connected to a second brain that does not yet exhibit self-awareness, forming a temporary triad:

original brain → organoid → new brain?

Two constraints seem necessary:

• a second brain with an existing, fully formed “self” would not enter such coupling, as its endogenous dynamics would dominate or prevent integration;

• the original brain would only attempt such coupling under extreme conditions, for example when its own survival or integrity is threatened, creating a “need” for transfer.

This leads to a central question:

If the self-related dynamics remain coherent while the surrounding network architecture — the patterns and clusters they normally interact with — gradually changes, and even after the original brain is disconnected, does the subjective continuity of “I” persist?

Or is this only an imitation without phenomenal continuity?

:small_blue_diamond: What I hope to learn from this discussion

I’m not trying to prove a futuristic scenario.

Rather, I want to understand:

• which parts contradict established neuroscience,

• which parts are speculative but not logically impossible,

• where conceptual room remains for inquiry,

• and which existing methods (fMRI, MEG, optogenetics, organoids, MEA interfacing, dynamic connectivity analysis) might allow testing of limited elements of this idea.

:small_blue_diamond: Key questions for the community

  1. Can an individually stable neural pattern of self-awareness be isolated?

  2. Is deep synchronization between a brain and an organoid feasible?

  3. Can a dynamic pattern “flow” into an organoid when the original activity is suppressed?

  4. If an organoid maintains such a pattern, is this functional transfer or imitation?

  5. What would linking such a stored pattern to another brain imply for subjective selfhood?

If this idea is naive, please say so.

If it contradicts fundamental principles — even better.

Any critique, references, or expert opinions would be greatly appreciated.

Thank you.